Transcriptomic and Proteomic Tools in the Study of Hg Toxicity: What Is Missing?

Transcriptomic and Proteomic Tools in the Study of Hg Toxicity: What Is Missing?

Blog Article

Mercury is a hazardous substance that has unique neurodevelopmental toxic effects in humans.However, the precise sequence of molecular events that culminate in Hg-induced neuropathology is still unknown.Though the omics studies have been generating an enormous amount of new data about Hg toxicity, our ability to interpret such a large quantity of information is still limited.In this opinion article, we ngetikin will reinforce the necessity of new high throughput and accurate analytical proteomic methodologies, especially, thiol and selenol-proteome.Overall, read more we posit that improvements in thiol- and selenol-proteomic analyses will be pivotal in identifying the primary cellular targets of Hg.

However, a better understanding of the complex cascades and molecular pathways involved in its toxicity will require extensive complementary studies in more complex systems.